Local iontophoretic administration of cytotoxic therapies to solid tumors

Author:

Byrne James D.12,R. Jajja Mohammad N.3,O’Neill Adrian T.3,Bickford Lissett R.3,Keeler Amanda W.4,Hyder Nabeel5,Wagner Kyle5,Deal Allison6,Little Ryan E.2,Moffitt Richard A.3,Stack Colleen378,Nelson Meredith3,Brooks Christopher R.9,Lee William10,Luft J. Chris13,Napier Mary E.3,Darr David3,Anders Carey K.311,Stack Richard3812,Tepper Joel E.35,Wang Andrew Z.35,Zamboni William C.34,Yeh Jen Jen31314,DeSimone Joseph M.13101415

Affiliation:

1. Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

2. School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

3. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

4. Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

5. Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

6. Lineberger Comprehensive Cancer Center Biostatistics and Clinical Data Management Core, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

7. School of Medicine, Duke University, Durham, NC 27708, USA.

8. Synecor LLC, Chapel Hill, NC 27517, USA.

9. Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

10. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

11. Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

12. Division of Cardiology, Department of Medicine, Duke University, Durham, NC 27708, USA.

13. Division of Surgical Oncology, Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

14. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

15. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.

Abstract

Local administration of cytotoxic drugs using iontophoresis results in drug accumulation and therapeutic efficacy in mouse models of pancreatic and breast cancer and favorable PK in a large animal model.

Funder

NIH Pioneer Award

NIH

PhRMA Foundation Fellowship

UNC Lineberger Comprehensive Cancer Center Postdoctoral Training

University Cancer Research Fund

Synecor LLC

National Defense Science and Engineering Graduate Fellowship

UNC Medical Scientists Training Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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