Oncolytic and Immunotherapeutic Vaccinia Induces Antibody-Mediated Complement-Dependent Cancer Cell Lysis in Humans-Reference-Cited by-同舟云学术

Oncolytic and Immunotherapeutic Vaccinia Induces Antibody-Mediated Complement-Dependent Cancer Cell Lysis in Humans

Published:2013-05-15 Issue:185 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kim Mi Kyung¹²,Breitbach Caroline J.³,Moon Anne³,Heo Jeong¹,Lee Yu Kyoung²,Cho Mong¹,Lee Jun Woo¹,Kim Seong-Geun¹,Kang Dae Hwan¹,Bell John C.³⁴,Park Byeong Ho⁵,Kirn David H.³,Hwang Tae-Ho¹²

Affiliation:

1. Pusan National University and Medical Research Institute, Pusan National University, 1-10 Ami-Dong, Seo-Gu, Busan 602-739, South Korea.

2. SillaJen Inc., Jangjeondong Geum Jeong-gu, Busan 609-735, South Korea.

3. Jennerex Inc., 450 Sansome Street, 16th Floor, San Francisco, CA 94111, USA.

4. Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.

5. Department of Diagnostic Radiology, College of Medicine, Dong-a University, Dongdaesingdong 3-ga Seo-Gu, Busan 602-739, South Korea.

Abstract

The oncolytic and immunotherapeutic vaccinia virus Pexa-Vec (JX-594) induces antibody-mediated complement-dependent cancer cell cytolysis in rabbits and cancer patients, prolonging their survival.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference72 articles.

1. Novel cancer immunotherapy agents with survival benefit: recent successes and next steps

2. Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

3. Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

4. Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer

5. Clinical development of gene therapy for colorectal cancer

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