Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus

Author:

Lande Roberto12,Ganguly Dipyaman13,Facchinetti Valeria1,Frasca Loredana2,Conrad Curdin1,Gregorio Josh13,Meller Stephan1,Chamilos Georgios2,Sebasigari Rosalie1,Riccieri Valeria4,Bassett Roland5,Amuro Hideki6,Fukuhara Shirou6,Ito Tomoki6,Liu Yong-Jun1,Gilliet Michel1378

Affiliation:

1. Department of Immunology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

2. Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanitá, 00161 Rome, Italy.

3. Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030, USA.

4. Division of Rheumatology, Department of Clinical Medicine and Therapy, University La Sapienza of Rome, 00161 Rome, Italy.

5. Department of Biostatistics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

6. First Department of Internal Medicine, Kansai Medical University, Osaka 579-8506, Japan.

7. Department of Melanoma Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

8. Department of Dermatology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

In systemic lupus erythematosus, neutrophils release peptide/self-DNA complexes that trigger plasmacytoid dendritic cell activation and autoantibody formation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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