Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus-Reference-Cited by-同舟云学术

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus

Published:2011-03-09 Issue:73 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lande Roberto¹²,Ganguly Dipyaman¹³,Facchinetti Valeria¹,Frasca Loredana²,Conrad Curdin¹,Gregorio Josh¹³,Meller Stephan¹,Chamilos Georgios²,Sebasigari Rosalie¹,Riccieri Valeria⁴,Bassett Roland⁵,Amuro Hideki⁶,Fukuhara Shirou⁶,Ito Tomoki⁶,Liu Yong-Jun¹,Gilliet Michel¹³⁷⁸

Affiliation:

1. Department of Immunology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

2. Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanitá, 00161 Rome, Italy.

3. Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030, USA.

4. Division of Rheumatology, Department of Clinical Medicine and Therapy, University La Sapienza of Rome, 00161 Rome, Italy.

5. Department of Biostatistics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

6. First Department of Internal Medicine, Kansai Medical University, Osaka 579-8506, Japan.

7. Department of Melanoma Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

8. Department of Dermatology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

In systemic lupus erythematosus, neutrophils release peptide/self-DNA complexes that trigger plasmacytoid dendritic cell activation and autoantibody formation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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