Disease Risk Factors Identified Through Shared Genetic Architecture and Electronic Medical Records

Author:

Li Li12,Ruau David J.12,Patel Chirag J.123,Weber Susan C.4,Chen Rong15,Tatonetti Nicholas P.6,Dudley Joel T.7,Butte Atul J.12

Affiliation:

1. Division of Systems Medicine, Department of Pediatrics, Stanford University School of Medicine, 1265 Welch Road, Stanford, CA 94305, USA.

2. Lucile Packard Children’s Hospital, Palo Alto, CA 94305, USA.

3. Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

4. Stanford Center for Clinical Informatics, Stanford University School of Medicine, Stanford, CA 94305, USA.

5. Personalis Inc., 1350 Willow Road, Suite 202, Menlo Park, CA 94025, USA.

6. Department of Biomedical Informatics, Columbia Initiative for Systems Biology, and Department of Medicine, Columbia University, 622 West 168th Street, VC5, New York, NY 10027, USA.

7. Department of Genetics and Genomics Sciences, Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1498, New York, NY 10029, USA.

Abstract

Twenty-six traits were associated with diseases through similarities in genetic variation and validated from electronic medical records.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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