A Hendra Virus G Glycoprotein Subunit Vaccine Protects African Green Monkeys from Nipah Virus Challenge

Author:

Bossart Katharine N.12,Rockx Barry34,Feldmann Friederike5,Brining Doug6,Scott Dana6,LaCasse Rachel6,Geisbert Joan B.78,Feng Yan-Ru9,Chan Yee-Peng9,Hickey Andrew C.12,Broder Christopher C.9,Feldmann Heinz310,Geisbert Thomas W.78

Affiliation:

1. Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

2. National Emerging Infectious Diseases Laboratories Institute, Boston University School of Medicine, Boston, MA 02118, USA.

3. Laboratory of Virology, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.

4. Sealy Center for Vaccine Development, Departments of Pathology and Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555–0610, USA.

5. Offices of Operations and Management, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.

6. Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.

7. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77550, USA.

8. Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77550, USA.

9. Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA.

10. Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, MB R3T 2N2, Canada.

Abstract

The Hendra virus attachment G glycoprotein fully protects nonhuman primates from lethal Nipah virus challenge.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference35 articles.

1. Hendra and Nipah viruses: different and dangerous

2. B. T. Eaton J. S. Mackenzie L.-F. Wang Henipaviruses in Fields Virology D.M. Knipe P.M. Howley Eds. (Lippincott Williams & Wilkins Philadelphia 2007) pp. 1587–1600.

3. Pteropid Bats are Confirmed as the Reservoir Hosts of Henipaviruses: A Comprehensive Experimental Study of Virus Transmission

4. Henipaviruses: Emerging paramyxoviruses associated with fruit bats.;Field H. E.;Curr. Top. Microbiol. Immunol.,2007

5. Pathology of acute henipavirus infection in humans and animals.;Wong K. T.;Patholog. Res. Int.,2011

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