Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer-Reference-Cited by-同舟云学术

Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer

Published:2012-12-12 Issue:164 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Blatner Nichole R.¹,Mulcahy Mary F.²,Dennis Kristen L.¹,Scholtens Denise³,Bentrem David J.⁴⁵,Phillips Joseph D.⁴,Ham Soo¹,Sandall Barry P.¹,Khan Mohammad W.¹,Mahvi David M.⁴,Halverson Amy L.⁴,Stryker Steven J.⁴,Boller Anne-Marie⁴,Singal Ashima¹,Sneed Rebekka K.¹,Sarraj Bara⁶,Ansari Mohammed Javeed⁶,Oft Martin⁷,Iwakura Yoichiro⁸,Zhou Liang⁹,Bonertz Andreas¹⁰,Beckhove Philipp¹¹⁰,Gounari Fotini¹¹,Khazaie Khashayarsha¹⁵

Affiliation:

1. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 303 East Superior Street, Chicago, IL 60611, USA.

2. Department of Hematology/Oncology, Northwestern Medical Faculty Foundation, 676 North Saint Clair, 8th Floor, Chicago, IL 60611, USA.

3. Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 North Lake Shore Drive, Suite 1400, Chicago, IL 60611, USA.

4. Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

5. Jesse Brown VA Medical Center, 820 South Damen Avenue, Chicago, IL 60612, USA.

6. Division of Nephrology and Organ Transplantation, Feinberg School of Medicine, Northwestern University, 300 East Superior Street, Chicago, IL 60611, USA.

7. Targenics Inc., 409 Illinois, Suite 5052, San Francisco, CA 94158, USA.

8. Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.

9. Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Ward 3-120, Chicago, IL 60611, USA.

10. Division of Translational Immunology, German Cancer Research Center and National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.

11. Department of Medicine, Section of Rheumatology, University of Chicago, 5841 South Maryland Avenue, MC 0930, Chicago, IL 60637, USA.

Abstract

T regs that expand in human colon cancer have proinflammatory properties and contribute to tumor progression.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference55 articles.

1. Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma.;Bonertz A.;J. Clin. Invest.,2009

2. The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer

3. Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients.;Ling K. L.;Cancer Immun.,2007

4. Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma

5. Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

Cited by 167 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology;Cell Communication and Signaling;2024-02-06

2. Sirtuin2 suppresses the polarization of regulatory T cells toward T helper 17 cells through repressing the expression of signal transducer and activator of transcription 3 in a mouse colitis model;Immunity, Inflammation and Disease;2024-02

3. Homeostatic, repertoire and transcriptional relationships between colon T regulatory cell subsets;Proceedings of the National Academy of Sciences;2023-12-08

4. The IL-17 family in diseases: from bench to bedside;Signal Transduction and Targeted Therapy;2023-10-11

5. TH17 cell immune adaptation;Current Opinion in Immunology;2023-08