Model System to Define Pharmacokinetic Requirements for Antimalarial Drug Efficacy-Reference-Cited by-同舟云学术

Model System to Define Pharmacokinetic Requirements for Antimalarial Drug Efficacy

Published:2013-10-02 Issue:205 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bakshi Rahul P.¹²,Nenortas Elizabeth¹,Tripathi Abhai K.²³,Sullivan David J.²³,Shapiro Theresa A.¹²³⁴

Affiliation:

1. Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA.

2. Johns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21205, USA.

3. Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD 21205, USA.

4. Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205, USA.

Abstract

An in vitro system can determine the pharmacokinetic drivers of antimalarial drug pharmacodynamics, leading to more rationally developed new drug candidates.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference49 articles.

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4. Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV

5. Genome sequence of the human malaria parasite Plasmodium falciparum

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