Blocking Macrophage Leukotriene B 4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension-Reference-Cited by-同舟云学术

Blocking Macrophage Leukotriene B 4 Prevents Endothelial Injury and Reverses Pulmonary Hypertension

Published:2013-08-28 Issue:200 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Tian Wen¹,Jiang Xinguo¹,Tamosiuniene Rasa¹,Sung Yon K.¹,Qian Jin¹,Dhillon Gundeep²,Gera Lajos³,Farkas Laszlo⁴,Rabinovitch Marlene²,Zamanian Roham T.²,Inayathullah Mohammed²,Fridlib Marina²,Rajadas Jayakumar²,Peters-Golden Marc⁵,Voelkel Norbert F.⁴,Nicolls Mark R.¹²

Affiliation:

1. Veterans Affairs Palo Alto Health Care System/Stanford University, Palo Alto, CA 94304, USA.

2. Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. University of Colorado at Denver Health Sciences Center, Aurora, CO 80045, USA.

4. Virginia Commonwealth University, Richmond, VA 23220, USA.

5. University of Michigan Health System, Ann Arbor, MI 48109, USA.

Abstract

In a rat model of pulmonary hypertension, inhibition of LTB 4 synthesis in macrophages that accumulate in lung tissue reverses the disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference83 articles.

1. Mechanisms of disease: pulmonary arterial hypertension

2. Autoimmunity and pulmonary hypertension: a perspective

3. Inflammation, Growth Factors, and Pulmonary Vascular Remodeling

4. Regulatory T Cells Limit Vascular Endothelial Injury and Prevent Pulmonary Hypertension

5. Pulmonary hypertension and inflammation

Cited by 209 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Crosstalk between cytokines, inflammation and pulmonary arterial hypertension in heart transplant patients;Cytokine;2024-10

2. Inhalable SPRAY nanoparticles by modular peptide assemblies reverse alveolar inflammation in lethal Gram-negative bacteria infection;Science Advances;2024-09-13

3. Macrophages in vascular disease: Roles of mitochondria and metabolic mechanisms;Vascular Pharmacology;2024-09

4. Unique intestinal microflora and metabolic profile in different stages of hypertension reveal potential biomarkers for early diagnosis and prognosis;Journal of Medical Microbiology;2024-08-30

5. Leukotriene B4: A potential mediator and biomarker for cardiac allograft vasculopathy;The Journal of Heart and Lung Transplantation;2024-08