Systematic Analysis of Challenge-Driven Improvements in Molecular Prognostic Models for Breast Cancer-Reference-Cited by-同舟云学术

Systematic Analysis of Challenge-Driven Improvements in Molecular Prognostic Models for Breast Cancer

Published:2013-04-17 Issue:181 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Margolin Adam A.¹,Bilal Erhan²,Huang Erich¹³⁴,Norman Thea C.¹,Ottestad Lars⁵,Mecham Brigham H.¹⁶,Sauerwine Ben⁷,Kellen Michael R.¹,Mangravite Lara M.¹,Furia Matthew D.¹⁸,Vollan Hans Kristian Moen⁵⁹¹⁰¹¹,Rueda Oscar M.¹¹,Guinney Justin¹,Deflaux Nicole A.¹,Hoff Bruce¹,Schildwachter Xavier¹,Russnes Hege G.⁹¹⁰¹²,Park Daehoon¹³,Vang Veronica O.⁹¹⁰,Pirtle Tyler⁷,Youseff Lamia⁷,Citro Craig⁷,Curtis Christina¹⁴,Kristensen Vessela N.⁹¹⁰¹⁵,Hellerstein Joseph⁷,Friend Stephen H.¹,Stolovitzky Gustavo²,Aparicio Samuel¹⁶¹⁷¹⁸,Caldas Carlos¹¹¹⁹²⁰,Børresen-Dale Anne-Lise⁹¹⁰

Affiliation:

1. Sage Bionetworks, 1100 Fairview Avenue North, MS: M1-C108, Seattle, WA 98109, USA.

2. Functional Genomics and Systems Biology, IBM Computational Biology Center, P. O. Box 218, Yorktown Heights, NY 10598, USA.

3. Institute for Genome Sciences & Policy, Duke University, Durham, NC 27708, USA.

4. Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.

5. Department of Oncology, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, 0450 Oslo, Norway.

6. Trialomics, LLC, Seattle, WA 98103, USA.

7. Google Inc., 651 North 34th Street, Seattle, WA 98103, USA.

8. Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.

9. Department of Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway.

10. K.G. Jebsen Centre for Breast Cancer Research, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0313 Oslo, Norway.

11. Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

12. Department of Pathology, Oslo University Hospital, 0450 Oslo, Norway.

13. Department of Pathology, Drammen Hospital, Vestre Viken HF, 3004 Drammen, Norway.

14. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

15. Department of Clinical Molecular Oncology, Division of Medicine, Akershus University Hospital, 1478 Ahus, Norway.

16. Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.

17. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

18. Genome Sciences Centre, BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.

19. Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 2QQ, UK.

20. Cambridge Experimental Cancer Medicine Centre, Cambridge CB2 0RE, UK.

Abstract

An open challenge to model breast cancer prognosis revealed that collaboration and transparency enhanced the power of prognostic models.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference46 articles.

1. Global estimates of cancer prevalence for 27 sites in the adult population in 2008

2. Molecular portraits of human breast tumours

3. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

4. A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

5. A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer

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