A Plasmablast Biomarker for Nonresponse to Antibody Therapy to CD20 in Rheumatoid Arthritis

Author:

Owczarczyk Kasia1,Lal Preeti2,Abbas Alexander R.3,Wolslegel Kristen1,Holweg Cecile T. J.1,Dummer Wolfgang2,Kelman Ariella2,Brunetta Paul2,Lewin-Koh Nicholas3,Sorani Marco1,Leong Diane4,Fielder Paul5,Yocum David2,Ho Carole2,Ortmann Ward1,Townsend Michael J.1,Behrens Timothy W.1

Affiliation:

1. Department of Immunology Biomarker Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

2. Department of Clinical Science, Genentech Inc., South San Francisco, CA 94080, USA.

3. Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA.

4. Department of Sample Repository, Genentech Inc., South San Francisco, CA 94080, USA.

5. Department of Development Sciences, Genentech Inc., South San Francisco, CA 94080, USA.

Abstract

Plasmablast biomarkers predict whether rheumatoid arthritis patients will respond to therapeutic antibodies to CD20.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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