Synthetic Generation of Influenza Vaccine Viruses for Rapid Response to Pandemics

Author:

Dormitzer Philip R.1,Suphaphiphat Pirada1,Gibson Daniel G.234,Wentworth David E.2,Stockwell Timothy B.2,Algire Mikkel A.2,Alperovich Nina2,Barro Mario5,Brown David M.2,Craig Stewart1,Dattilo Brian M.5,Denisova Evgeniya A.2,De Souza Ivna1,Eickmann Markus6,Dugan Vivien G.2,Ferrari Annette1,Gomila Raul C.17,Han Liqun1,Judge Casey1,Mane Sarthak1,Matrosovich Mikhail6,Merryman Chuck3,Palladino Giuseppe1,Palmer Gene A.1,Spencer Terika18,Strecker Thomas6,Trusheim Heidi8,Uhlendorff Jennifer6,Wen Yingxia1,Yee Anthony C.2,Zaveri Jayshree2,Zhou Bin2,Becker Stephan6,Donabedian Armen5,Mason Peter W.1,Glass John I.2,Rappuoli Rino17,Venter J. Craig234

Affiliation:

1. Novartis Vaccines and Diagnostics, Cambridge, MA 02139, USA.

2. The J. Craig Venter Institute, Rockville, MD 20850, USA.

3. The J. Craig Venter Institute, San Diego, CA 92121, USA.

4. Synthetic Genomics Inc., La Jolla, CA 92037, USA.

5. Biomedical Advanced Research and Development Authority, U.S. Department of Health and Human Services, Washington, DC 20201, USA.

6. Institut für Virologie, Philipps-Universität Marburg, D-35032 Marburg, Germany.

7. Novartis Vaccines and Diagnostics, 53100 Siena, Italy.

8. Novartis Vaccines and Diagnostics, Holly Springs, NC 25740, USA.

Abstract

Synthesis of viral genes from sequence information allows rapid generation of influenza vaccine viruses, facilitating rapid responses to influenza pandemics.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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