Genetic validation of a therapeutic target in a mouse model of ALS-Reference-Cited by-同舟云学术

Genetic validation of a therapeutic target in a mouse model of ALS

Published:2014-08-06 Issue:248 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

de Boer A. Sophie¹²,Koszka Kathryn¹,Kiskinis Evangelos¹,Suzuki Naoki¹,Davis-Dusenbery Brandi N.¹,Eggan Kevin¹

Affiliation:

1. The Howard Hughes Medical Institute, Harvard Stem Cell Institute, Stanley Center for Psychiatric Research, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

2. Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.

Abstract

The DP1 receptor mediates toxicity of microglia in human stem cell and transgenic animal models of amyotrophic lateral sclerosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference70 articles.

1. A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis

2. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

3. Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

4. Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

5. TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

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