A Factor XIIa Inhibitory Antibody Provides Thromboprotection in Extracorporeal Circulation Without Increasing Bleeding Risk-Reference-Cited by-同舟云学术

A Factor XIIa Inhibitory Antibody Provides Thromboprotection in Extracorporeal Circulation Without Increasing Bleeding Risk

Published:2014-02-05 Issue:222 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Larsson Magnus¹²,Rayzman Veronika³,Nolte Marc W.⁴,Nickel Katrin F.¹⁵⁶,Björkqvist Jenny¹⁵,Jämsä Anne¹⁵,Hardy Matthew P.³,Fries Marion⁴,Schmidbauer Stefan⁴,Hedenqvist Patricia⁷,Broomé Michael²⁸,Pragst Ingo⁴,Dickneite Gerhard⁴,Wilson Michael J.³,Nash Andrew D.³,Panousis Con³,Renné Thomas¹⁵⁶

Affiliation:

1. Department of Molecular Medicine and Surgery, Karolinska Institutet and University Hospital, SE-171 76 Stockholm, Sweden.

2. ECMO Department, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

3. CSL Limited, Bio21 Institute, 30 Flemington Road, Parkville, Victoria 3010, Australia.

4. CSL Behring GmbH, Emil-von-Behring-Straße 76, 35041 Marburg, Germany.

5. Center of Molecular Medicine, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

6. Institute of Clinical Chemistry, University Hospital Hamburg-Eppendorf, D-20246 Hamburg, Germany.

7. Department of Clinical Sciences, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden.

8. Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.

Abstract

Blocking the enzyme that initiates the intrinsic coagulation pathway protects against thrombosis in bypass systems and does not cause excess bleeding in vivo.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference65 articles.

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4. In vivo roles of factor XII

5. Role of Tissue Factor in Hemostasis, Thrombosis, and Vascular Development

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