Evaluation of DNA from the Papanicolaou Test to Detect Ovarian and Endometrial Cancers

Author:

Kinde Isaac1,Bettegowda Chetan12,Wang Yuxuan1,Wu Jian13,Agrawal Nishant14,Shih Ie-Ming5,Kurman Robert5,Dao Fanny6,Levine Douglas A.6,Giuntoli Robert7,Roden Richard5,Eshleman James R.5,Carvalho Jesus Paula8,Marie Suely Kazue Nagahashi89,Papadopoulos Nickolas1,Kinzler Kenneth W.1,Vogelstein Bert1,Diaz Luis A.1

Affiliation:

1. The Ludwig Center for Cancer Genetics and Therapeutics, The Swim Across America Laboratory at Johns Hopkins, and The Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA.

2. Department of Neurosurgery, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

3. MyGenostics Inc., 801 West Baltimore Street, Suite 502L, Baltimore, MD 21201, USA.

4. Department of Otolaryngology–Head and Neck Surgery, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

5. Department of Pathology, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

6. Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

7. Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA.

8. Institute of Cancer of Sao Paulo State, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil.

9. Departments of Pathology and Neurology, School of Medicine, University of Sao Paulo, Sao Paulo 01246903, Brazil.

Abstract

Mutant DNA from ovarian and endometrial tumors can be detected in Pap smear specimens through massively parallel sequencing.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.

1. European Guidelines for Quality Assurance in Cervical Cancer Screening. Second Edition—Summary Document

2. R. M. DeMay Practical Principles of Cytopathology (ASCP Press Chicago 2010).

3. N. Howlader A. M. Noone M. Krapcho N. Neyman R. Aminou S. F. Altekruse C. L. Kosary J. Ruhl Z. Tatalovich H. Cho A. Mariotto M. P. Eisner D. R. Lewis H. S. Chen E. J. Feuer K. A. Cronin SEER Cancer Statistics Review 1975-2009 (Vintage 2009 Populations); http://seer.cancer.gov/csr/1975_2009_pops09/.

4. Global estimates of cancer prevalence for 27 sites in the adult population in 2008.;Bray F.;Int. J. Cancer,2012

5. International Agency for Research on Cancer GLOBOCAN 2008 v1.2 Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10; http://globocan.iarc.fr.

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