A Biophysical Indicator of Vaso-occlusive Risk in Sickle Cell Disease

Author:

Wood David K.1,Soriano Alicia2,Mahadevan L.34,Higgins John M.45,Bhatia Sangeeta N.167

Affiliation:

1. Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Special Hematology Laboratory, Brigham and Women’s Hospital, Boston, MA 02115, USA.

3. School of Engineering and Applied Sciences, Department of Physics, Department of Organismic and Evolutionary Biology, Wyss Institute for Biologically Inspired Engineering and Kavli Institute for Nanobio Science and Technology, Harvard University, Cambridge, MA 02138, USA.

4. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

5. Center for Systems Biology and Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

6. Howard Hughes Medical Institute, Department of Electrical Engineering and Computer Science and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

7. Division of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.

Abstract

Sickle cell patients are stratified according to risk of vaso-occlusion on the basis of the dynamic biophysical properties of their blood as measured ex vivo in a microfluidic system.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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