Pathogenesis of Lethal Cardiac Arrhythmias in Mecp2 Mutant Mice: Implication for Therapy in Rett Syndrome-Reference-Cited by-同舟云学术

Pathogenesis of Lethal Cardiac Arrhythmias in Mecp2 Mutant Mice: Implication for Therapy in Rett Syndrome

Published:2011-12-14 Issue:113 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

McCauley Mark D.¹²,Wang Tiannan¹,Mike Elise¹,Herrera Jose³,Beavers David L.¹²,Huang Teng-Wei⁴,Ward Christopher S.⁵,Skinner Steven⁶,Percy Alan K.⁷,Glaze Daniel G.⁸,Wehrens Xander H. T.¹²³,Neul Jeffrey L.¹³⁴⁵⁹

Affiliation:

1. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.

2. Department of Medicine (Cardiology), Baylor College of Medicine, Houston, TX 77030, USA.

3. Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA.

4. Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.

5. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

6. Greenwood Genetic Center, Greenwood, SC 29646, USA.

7. Department of Pediatrics (Neurology) and the Civitan International Research Center, University of Alabama, Birmingham, AL 35233, USA.

8. Department of Pediatrics (Neurology), Baylor College of Medicine, Houston, TX 77030, USA.

9. Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Lethal ventricular arrhythmias in a mouse model of Rett syndrome can be prevented by phenytoin, which blocks a persistent sodium current.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference42 articles.

1. Rett syndrome: Revised diagnostic criteria and nomenclature

2. Specific mutations in Methyl-CpG-Binding Protein 2 confer different severity in Rett syndrome

3. MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

4. Reduced Heart Rate Variability in Patients Affected with Rett Syndrome. A Possible Explanation for Sudden Death

5. Characterisation of breathing and associated central autonomic dysfunction in the Rett disorder

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