Targeting Cancer with a Lupus Autoantibody-Reference-Cited by-同舟云学术

Targeting Cancer with a Lupus Autoantibody

Published:2012-10-24 Issue:157 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hansen James E.¹²,Chan Grace³,Liu Yanfeng¹,Hegan Denise C.¹,Dalal Shibani¹,Dray Eloise⁴,Kwon Youngho⁴,Xu Yuanyuan⁴,Xu Xiaohua⁵,Peterson-Roth Elizabeth¹,Geiger Erik¹,Liu Yilun⁵,Gera Joseph³⁶,Sweasy Joann B.¹²⁷⁸,Sung Patrick¹²⁴,Rockwell Sara¹²⁹,Nishimura Robert N.³¹⁰,Weisbart Richard H.³,M. Glazer Peter¹²⁸

Affiliation:

1. Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520, USA.

2. Yale Cancer Center, Yale School of Medicine, New Haven, CT 06520, USA.

3. Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda, CA 91343, USA.

4. Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, CT 06520, USA.

5. Division of Radiation Biology, Beckman Research Institute, Duarte, CA 91010, USA.

6. David Geffen School of Medicine, Jonsson Comprehensive Cancer Center, and Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.

7. Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.

8. Department of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.

9. Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520, USA.

10. Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Abstract

A cell-penetrating lupus anti-DNA antibody inhibits DNA repair, sensitizes cancer cells to DNA-damaging therapy in vitro and in vivo, and is synthetically lethal to BRCA2-deficient human cancer cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference32 articles.

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