T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures-Reference-Cited by-同舟云学术

T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures

Published:2012-02-15 Issue:121 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Tringham Elizabeth¹,Powell Kim L.²,Cain Stuart M.³,Kuplast Kristy¹,Mezeyova Janette¹,Weerapura Manjula¹,Eduljee Cyrus¹,Jiang Xinpo¹,Smith Paula¹,Morrison Jerrie-Lynn¹,Jones Nigel C.²,Braine Emma²,Rind Gil²,Fee-Maki Molly¹,Parker David¹,Pajouhesh Hassan¹,Parmar Manjeet¹,O’Brien Terence J.²,Snutch Terrance P.³

Affiliation:

1. Zalicus Pharmaceuticals Ltd., Suite 301, 2389 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.

2. Department of Medicine, Royal Melbourne Hospital, University of Melbourne, 4th Floor, Clinical Sciences Building, Royal Parade, Parkville, Victoria 3050, Australia.

3. Michael Smith Laboratories, University of British Columbia, Room 219, 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada.

Abstract

Two high-affinity T-type calcium channel blockers attenuate neural activity in the thalamus and suppress seizures in a genetic model of absence epilepsy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference76 articles.

1. Ion Channels in Epilepsy

2. Absence seizures: A review of recent reports with new concepts

3. Modulators of Voltage-Dependent Calcium Channels for the Treatment of Nervous System Diseases

4. Curing epilepsy: Progress and future directions

5. Role of voltage-gated calcium channels in epilepsy

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