Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles-Reference-Cited by-同舟云学术

Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles

Published:2014-03-26 Issue:229 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zasadil Lauren M.¹²,Andersen Kristen A.²,Yeum Dabin¹,Rocque Gabrielle B.³,Wilke Lee G.⁴⁵,Tevaarwerk Amye J.³⁵,Raines Ronald T.⁵⁶,Burkard Mark E.³⁵,Weaver Beth A.¹⁵

Affiliation:

1. Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI 53705, USA.

2. Molecular and Cellular Pharmacology Training Program, University of Wisconsin, Madison, WI 53705, USA.

3. Department of Medicine, University of Wisconsin, Madison, WI 53705, USA.

4. Department of Surgery, University of Wisconsin, Madison, WI 53705, USA.

5. Carbone Cancer Center, University of Wisconsin, Madison, WI 53705, USA.

6. Departments of Biochemistry and Chemistry, University of Wisconsin, Madison, WI 53705, USA.

Abstract

The chemotherapy drug paclitaxel causes tumor regression and cell death by inducing high rates of chromosome missegregation on multipolar spindles.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference55 articles.

1. From taxol to taxol®: The changing identities and ownership of an anti-cancer drug

2. Comparison of weekly versus every 3 weeks paclitaxel in the treatment of advanced solid tumors: A meta-analysis

3. Promotion of microtubule assembly in vitro by taxol

4. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations.

5. Taxol stabilizes microtubules in mouse fibroblast cells.

Cited by 313 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Protective effects of silymarin against paclitaxel-induced cardiac toxicity;Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas;2024-09-30

2. Centrosome amplification primes ovarian cancer cells for apoptosis and potentiates the response to chemotherapy;PLOS Biology;2024-09-05

3. A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer;Cell Chemical Biology;2024-09

4. Stem cell mechanoadaptation - Part A - Effect of microtubule stabilization and volume changing stresses on cytoskeletal remodeling;2024-07-29

5. Failure to progress: breast and prostate cancer cell lines in developing targeted therapies;Cancer and Metastasis Reviews;2024-07-26