Intratumor Heterogeneity: Seeing the Wood for the Trees

Author:

Yap Timothy A.1,Gerlinger Marco23,Futreal P. Andrew4,Pusztai Lajos5,Swanton Charles26

Affiliation:

1. Department of Medicine, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT, UK.

2. Translational Cancer Therapeutics Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.

3. Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.

4. Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

5. Department of Breast Medical Oncology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

6. University College London Cancer Institute, Huntley Street, London WC1E 6BT, UK.

Abstract

Intratumor genetic heterogeneity impedes development of new therapeutics and biomarkers that predict drug response.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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