Genotype-based treatment of type 2 diabetes with an α 2A -adrenergic receptor antagonist-Reference-Cited by-同舟云学术

Genotype-based treatment of type 2 diabetes with an α 2A -adrenergic receptor antagonist

Published:2014-10-08 Issue:257 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Tang Yunzhao¹²,Axelsson Annika S.¹,Spégel Peter¹,Andersson Lotta E.¹,Mulder Hindrik¹,Groop Leif C.¹,Renström Erik¹,Rosengren Anders H.¹

Affiliation:

1. Department of Clinical Sciences, Lund University, SE-20502 Malmö, Sweden.

2. 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics (Ministry of Health), Key Laboratory of Hormones and Development, Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China.

Abstract

The α 2A -adrenergic receptor antagonist yohimbine improves insulin secretion in type 2 diabetics carrying the ADRA2A risk variant.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference30 articles.

1. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

2. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

3. Genetics of diabetes – Are we missing the genes or the disease?

4. Initial impact of the sequencing of the human genome

5. Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis

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