A HIF-Regulated VHL-PTP1B-Src Signaling Axis Identifies a Therapeutic Target in Renal Cell Carcinoma-Reference-Cited by-同舟云学术

A HIF-Regulated VHL-PTP1B-Src Signaling Axis Identifies a Therapeutic Target in Renal Cell Carcinoma

Published:2011-06 Issue:85 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Suwaki Natsuko¹,Vanhecke Elsa¹,Atkins Katelyn M.²,Graf Manuela¹,Swabey Katherine¹,Huang Paul¹,Schraml Peter³,Moch Holger³,Cassidy Amy Mulick⁴,Brewer Daniel⁵,Al-Lazikani Bissan⁶,Workman Paul⁶,De-Bono Johann⁴,Kaye Stan B.⁴,Larkin James⁷,Gore Martin. E.⁷,Sawyers Charles L.⁸,Nelson Peter⁹,Beer Tomasz M.¹⁰,Geng Hao¹⁰,Gao Lina¹⁰,Qian David Z.¹⁰,Alumkal Joshi J.¹⁰,Thomas Gary²,Thomas George V.¹¹⁰

Affiliation:

1. Section of Cell and Molecular Biology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.

2. Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.

3. Institute of Surgical Pathology, University Hospital Zurich, Zurich CH-8091, Switzerland.

4. Section of Medicine, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.

5. Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.

6. Cancer Research UK Center for Therapeutics, Division of Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.

7. Royal Marsden Hospital, London SW3 6JJ, UK.

8. Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

9. Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

10. OHSU Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA.

Abstract

Signaling through the VHL-PTP1B-Src pathway in renal cell carcinomas may determine sensitivity to Src inhibitors and provide a basis for treatment planning.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference46 articles.

1. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): A literature review

2. Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease

3. Surveillance following radical or partial nephrectomy for renal cell carcinoma

4. Renal Cystic Diseases and Renal Neoplasms: A Mini-Review

5. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

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