Dopamine Gene Therapy for Parkinson’s Disease in a Nonhuman Primate Without Associated Dyskinesia

Author:

Jarraya Béchir1234,Boulet Sabrina12,Scott Ralph G.5,Jan Caroline12,Bonvento Gilles12,Azzouz Mimoun6,Miskin James E.5,Shin Masahiro12,Delzescaux Thierry12,Drouot Xavier37,Hérard Anne-Sophie12,Day Denise M.5,Brouillet Emmanuel12,Kingsman Susan M.5,Hantraye Philippe12,Mitrophanous Kyriacos A.5,Mazarakis Nicholas D.8,Palfi Stéphane1234

Affiliation:

1. CEA, DSV, I²BM, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France.

2. CEA, CNRS URA 2210, F-92265 Fontenay-aux-Roses, France.

3. Universite Paris 12, Faculte de Medecine, F-94010 Creteil, France.

4. AP-HP, Groupe Henri-Mondor Albert-Chenevier, UF Neurochirurgie Fonctionnelle, F-94010 Creteil, France.

5. Oxford BioMedica Ltd., Medawar Centre, Oxford Science Park, Oxford OX4 4GA, UK.

6. Neurology Unit, Medical School, Sheffield University, Sheffield S10 2RX, UK.

7. AP-HP, Groupe Henri-Mondor Albert-Chenevier, Service de Neurophysiologie, F-94010 Creteil, France.

8. Department of Gene Therapy, Division of Medicine, Imperial College London, St Mary’s Campus, London W2 1PG, UK.

Abstract

A gene therapy approach for the treatment of Parkinson’s disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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