Vitamin D Deficiency Induces Early Signs of Aging in Human Bone, Increasing the Risk of Fracture-Reference-Cited by-同舟云学术

Vitamin D Deficiency Induces Early Signs of Aging in Human Bone, Increasing the Risk of Fracture

Published:2013-07-10 Issue:193 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Busse Björn¹²,Bale Hrishikesh A.²,Zimmermann Elizabeth A.¹²³,Panganiban Brian²,Barth Holly D.²³,Carriero Alessandra²,Vettorazzi Eik⁴,Zustin Josef⁵,Hahn Michael¹,Ager Joel W.²,Püschel Klaus⁶,Amling Michael¹,Ritchie Robert O.²³

Affiliation:

1. Department of Osteology and Biomechanics, University Medical Center Hamburg, D-22529 Hamburg, Germany.

2. Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

3. Department of Materials Science and Engineering, University of California, Berkeley, CA 94720, USA.

4. Department of Medical Biometry and Epidemiology, University Medical Center Hamburg, D-20246 Hamburg, Germany.

5. Institute of Pathology, University Medical Center Hamburg, D-20246 Hamburg, Germany.

6. Department of Forensic Medicine, University Medical Center Hamburg, D-20246 Hamburg, Germany.

Abstract

In addition to decreasing bone mass, vitamin D deficiency causes early aging of the remaining mineralized bone and leads to severe losses in fracture resistance.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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