Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides-Reference-Cited by-同舟云学术

Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides

Published:2014-11-12 Issue:262 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zirafi Onofrio¹,Kim Kyeong-Ae¹,Roan Nadia R.²³,Kluge Silvia F.¹,Müller Janis A.¹,Jiang Shibo⁴,Mayer Benjamin⁵,Greene Warner C.²⁶,Kirchhoff Frank¹,Münch Jan¹

Affiliation:

1. Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.

2. Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA.

3. Department of Urology, University of California, San Francisco, San Francisco, CA 94158, USA.

4. Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.

5. Institute of Epidemiology and Medical Biometry, Ulm University, 89081 Ulm, Germany.

6. Departments of Medicine and Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

Endogenous amyloids in semen impair the antiretroviral efficacy of drugs targeting HIV directly, but do not impair maraviroc, which targets the cellular CCR5 receptor.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.

1. Accelerating Next-Generation Vaccine Development for Global Disease Prevention

2. Whither or Wither Microbicides?

3. Microbicides: still a long road to success

4. The Molecular Basis of Nonoxynol‐9–Induced Vaginal Inflammation and Its Possible Relevance to Human Immunodeficiency Virus Type 1 Transmission

5. PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial

Cited by 63 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Semen enhances transmitted/founder HIV-1 infection and only marginally reduces antiviral activity of broadly neutralizing antibodies;Journal of Virology;2024-04-16

2. gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity;Cellular & Molecular Immunology;2024-03-05

3. Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection;Science Advances;2023-07-07

4. Women for science and science for women: Gaps, challenges and opportunities towards optimizing pre-exposure prophylaxis for HIV-1 prevention;Frontiers in Immunology;2022-12-06

5. Carbosilane dendritic nanostructures, highly versatile platforms for pharmaceutical applications;WIREs Nanomedicine and Nanobiotechnology;2022-11-23