HIV-1 Vaccines and Adaptive Trial Designs

Author:

Corey Lawrence123,Nabel Gary J.43,Dieffenbach Carl5,Gilbert Peter1,Haynes Barton F.6,Johnston Margaret5,Kublin James1,Lane H. Clifford7,Pantaleo Giuseppe8,Picker Louis J.9,Fauci Anthony S.10

Affiliation:

1. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

2. Department of Medicine, University of Washington, Seattle, WA 98109, USA.

3. These authors contributed equally to this work.

4. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

5. Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

6. Duke Human Vaccine Institute, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

7. Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

8. Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH-1015, Lausanne, Switzerland, and Swiss Vaccine Research Institute, 1011 Lausanne, Switzerland.

9. Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR 97205, USA.

10. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Development of an HIV vaccine could be accelerated by testing candidate vaccines using adaptive clinical trial designs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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