Ectopic Activation of Germline and Placental Genes Identifies Aggressive Metastasis-Prone Lung Cancers

Author:

Rousseaux Sophie1,Debernardi Alexandra1,Jacquiau Baptiste1,Vitte Anne-Laure1,Vesin Aurélien1,Nagy-Mignotte Hélène2,Moro-Sibilot Denis2,Brichon Pierre-Yves2,Lantuejoul Sylvie2,Hainaut Pierre3,Laffaire Julien4,de Reyniès Aurélien4,Beer David G.5,Timsit Jean-François12,Brambilla Christian12,Brambilla Elisabeth12,Khochbin Saadi1

Affiliation:

1. INSERM, U823; Université Joseph Fourier, Grenoble 1; Institut Albert Bonniot, Grenoble F-38700, France.

2. Grenoble University Hospital (CHU), Grenoble F-38700, France.

3. International Prevention Research Institute, Lyon F-69006, France.

4. Ligue Nationale Contre le Cancer, Cartes d’Identité des Tumeurs Program, Paris F-75013, France.

5. Thoracic Surgery, University of Michigan, 6304 Cancer Center, Ann Arbor, MI 48109, USA.

Abstract

Large-scale detection of ectopic gene activations reveals a source of potential cancer biomarkers and correlates with aggressive metastasis-prone lung tumors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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