Selective Activation of Adenosine A 2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis-Reference-Cited by-同舟云学术

Selective Activation of Adenosine A 2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis

Published:2012-08-08 Issue:146 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Flögel Ulrich¹,Burghoff Sandra¹,van Lent Peter L. E. M.²,Temme Sebastian¹,Galbarz Lisa¹,Ding Zhaoping¹,El-Tayeb Ali³,Huels Sandra¹,Bönner Florian¹,Borg Nadine¹,Jacoby Christoph¹,Müller Christa E.³,van den Berg Wim B.²,Schrader Jürgen¹

Affiliation:

1. Department of Molecular Cardiology, Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany.

2. Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen 6525, Netherlands.

3. PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, Bonn 53121, Germany.

Abstract

Phosphorylated adenosine A 2A receptor agonists suppressed inflammation in a model of arthritis without A 2A -mediated vasodilatory side effects.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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