Identification of a New Modulator of the Intercalated Disc in a Zebrafish Model of Arrhythmogenic Cardiomyopathy-Reference-Cited by-同舟云学术

Identification of a New Modulator of the Intercalated Disc in a Zebrafish Model of Arrhythmogenic Cardiomyopathy

Published:2014-06-11 Issue:240 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Asimaki Angeliki¹,Kapoor Sudhir¹,Plovie Eva²,Karin Arndt Anne²,Adams Edward²,Liu ZhenZhen²,James Cynthia A.³,Judge Daniel P.³,Calkins Hugh³,Churko Jared⁴,Wu Joseph C.⁴,MacRae Calum A.²,Kléber André G.¹,Saffitz Jeffrey E.¹

Affiliation:

1. Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

2. Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Harvard Stem Cell Institute, and Broad Institute of Harvard and MIT, Boston, MA 02115, USA.

3. Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.

4. Stanford Cardiovascular Institute, Departments of Medicine and Radiology, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Drug screening in a zebrafish model of arrhythmogenic cardiomyopathy identified a small molecule that remodels the intercalated disc.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference37 articles.

1. Arrhythmogenic right ventricular cardiomyopathy

2. The Pathobiology of Arrhythmogenic Cardiomyopathy

3. Left-Dominant Arrhythmogenic Cardiomyopathy

4. A New Diagnostic Test for Arrhythmogenic Right Ventricular Cardiomyopathy

5. Gap junctions and arrhythmogenic cardiomyopathy

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