Hematopoietic Stem Cell Origin of BRAF V600E Mutations in Hairy Cell Leukemia-Reference-Cited by-同舟云学术

Hematopoietic Stem Cell Origin of BRAF V600E Mutations in Hairy Cell Leukemia

Published:2014-05-28 Issue:238 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chung Stephen S.¹²,Kim Eunhee¹,Park Jae H.²,Chung Young Rock¹,Lito Piro³,Teruya-Feldstein Julie⁴,Hu Wenhuo¹,Beguelin Wendy⁵,Monette Sebastien⁶,Duy Cihangir⁵,Rampal Raajit¹²,Telis Leon¹,Patel Minal¹,Kim Min Kyung¹,Huberman Kety⁷,Bouvier Nancy¹⁴⁷,Berger Michael F.¹⁴⁷,Melnick Ari M.⁵,Rosen Neal³,Tallman Martin S.²,Park Christopher Y.¹⁴⁸⁹,Abdel-Wahab Omar¹²

Affiliation:

1. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

2. Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3. Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

4. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

5. Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA.

6. Tri-Institutional Laboratory of Comparative Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, Rockefeller University, New York, NY 10065, USA.

7. Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

8. Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

9. Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA.

Abstract

The cell of origin for the chronic lymphoproliferative disorder hairy cell leukemia is a long-term hematopoietic stem cell, as shown through human genetic data and murine genetic models.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference39 articles.

1. Surface immunoglobulins on hairy cells of 55 patients with hairy cell leukemia

2. Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing

3. VH gene expression in hairy cell leukaemia

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5. Evolving concepts in the pathogenesis of hairy-cell leukaemia

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