Inhibition of LTi Cell Development by CD25 Blockade Is Associated with Decreased Intrathecal Inflammation in Multiple Sclerosis

Author:

Perry Justin S. A.1,Han Sungpil12,Xu Quangang13,Herman Matthew L.1,Kennedy Lucy B.1,Csako Gyorgy4,Bielekova Bibiana1

Affiliation:

1. Neuroimmunological Diseases Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

2. School of Medicine, Pusan National University, Yangsan 626870, South Korea.

3. Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China.

4. Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Daclizumab inhibition of inflammation in human autoimmunity is associated with blockade of lymphoid tissue inducer cell development.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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