Neonatal Estradiol Stimulation Prevents Epilepsy in Arx Model of X-Linked Infantile Spasms Syndrome-Reference-Cited by-同舟云学术

Neonatal Estradiol Stimulation Prevents Epilepsy in Arx Model of X-Linked Infantile Spasms Syndrome

Published:2014-01-22 Issue:220 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Olivetti Pedro R.¹²,Maheshwari Atul¹,Noebels Jeffrey L.¹²³

Affiliation:

1. Blue Bird Circle Developmental Neurogenetics Laboratory, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.

2. Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.

3. Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Estradiol treatment of a mouse model of X-linked infantile spasms syndrome during the neonatal period prevents epilepsy in adulthood, restores interneurons, and alters mRNA levels of Arx targets.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference64 articles.

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2. Infantile spasms: A U.S. consensus report

3. Infantile spasms

4. Major Adverse Events Associated With Treatment of Infantile Spasms

5. Evidence-based guideline update: Medical treatment of infantile spasms: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society

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