Phosphorylated α-Synuclein in Parkinson’s Disease

Author:

Wang Yu12,Shi Min1,Chung Kathryn A.3,Zabetian Cyrus P.45,Leverenz James B.567,Berg Daniela89,Srulijes Karin89,Trojanowski John Q.10,Lee Virginia M.-Y.10,Siderowf Andrew D.11,Hurtig Howard11,Litvan Irene12,Schiess Mya C.13,Peskind Elaine R.67,Masuda Masami14,Hasegawa Masato14,Lin Xiangmin1,Pan Catherine1,Galasko Douglas15,Goldstein David S.16,Jensen Poul Henning17,Yang Hui1,Cain Kevin C.18,Zhang Jing1

Affiliation:

1. Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA.

2. Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

3. Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.

4. Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.

5. Department of Neurology, University of Washington School of Medicine, Seattle, WA 98104, USA.

6. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98105, USA.

7. Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.

8. Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.

9. German Center for Neurodegenerative Diseases, University of Tuebingen, 72076 Tuebingen, Germany.

10. Institute on Aging, Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

11. Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19107, USA.

12. Division of Movement Disorders, University of Louisville School of Medicine, Louisville, KY 40202, USA.

13. Department of Neurology, University of Texas Health Science Center, Houston, TX 77030, USA.

14. Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8585, Japan.

15. Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA.

16. Clinical Neurocardiology Section, Community Networks Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

17. Department of Medical Chemistry, Aarhus University, 8000 Aarhus C, Denmark.

18. Department of Biostatistics, University of Washington, Seattle, WA 98105, USA.

Abstract

An assay for detecting phosphorylated α-synuclein in CSF may help to diagnose Parkinson’s disease and determine disease severity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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