Rapid Cancer Detection by Topically Spraying a γ-Glutamyltranspeptidase–Activated Fluorescent Probe-Reference-Cited by-同舟云学术

Rapid Cancer Detection by Topically Spraying a γ-Glutamyltranspeptidase–Activated Fluorescent Probe

Published:2011-11-23 Issue:110 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Urano Yasuteru¹²,Sakabe Masayo³,Kosaka Nobuyuki⁴,Ogawa Mikako⁴,Mitsunaga Makoto⁴,Asanuma Daisuke¹,Kamiya Mako¹,Young Matthew R.⁵,Nagano Tetsuo³,Choyke Peter L.⁴,Kobayashi Hisataka⁴

Affiliation:

1. Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

2. Basic Research Program, Japan Science and Technology Agency, Tokyo 102-0075, Japan.

3. Graduate School of Pharmaceutical Science, The University of Tokyo, Tokyo 113-0033, Japan.

4. Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

5. Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute–Frederick, National Institutes of Health, Frederick, MD 21702, USA.

Abstract

A spirocyclic-caged, small-molecule imaging probe fluoresces upon cleavage by a cancer-specific enzyme and can be used during surgical or endoscopic tumor removal procedures.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference33 articles.

1. New Technologies for Human Cancer Imaging

2. Advances in Endoscopic Imaging of Colorectal Neoplasia

3. Imaging in the era of molecular oncology

4. New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging

5. Target-Cancer-Cell-Specific Activatable Fluorescence Imaging Probes: Rational Design and in Vivo Applications

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