Selective Targeting of TGF-β Activation to Treat Fibroinflammatory Airway Disease-Reference-Cited by-同舟云学术

Selective Targeting of TGF-β Activation to Treat Fibroinflammatory Airway Disease

Published:2014-06-18 Issue:241 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Minagawa Shunsuke¹,Lou Jianlong²,Seed Robert I.¹,Cormier Anthony¹,Wu Shenping³,Cheng Yifan³,Murray Lynne⁴⁵,Tsui Ping⁴,Connor Jane⁴,Herbst Ronald⁴,Govaerts Cedric⁵,Barker Tyren¹,Cambier Stephanie¹,Yanagisawa Haruhiko¹,Goodsell Amanda⁶,Hashimoto Mitsuo¹,Brand Oliver J.¹,Cheng Ran¹,Ma Royce¹,McKnelly Kate J.¹,Wen Weihua²,Hill Arthur⁷,Jablons David⁷,Wolters Paul⁶,Kitamura Hideya¹,Araya Jun⁸,Barczak Andrea J.⁶,Erle David J.⁶,Reichardt Louis F.⁹,Marks James D.²,Baron Jody L.⁶,Nishimura Stephen L.¹

Affiliation:

1. Department of Pathology, University of California, San Francisco, San Francisco, CA 94110, USA.

2. Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA.

3. The Keck Advanced Microscopy Laboratory, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94110, USA.

4. Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Gaithersburg, MD 20878, USA.

5. Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Cambridge CB21 6GH, UK.

6. Department of Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.

7. Department of Surgery, University of California, San Francisco, San Francisco, CA 94110, USA.

8. Department of Pulmonary Medicine, Jikei University, Tokyo 105 8461, Japan.

9. Genetics, Development, and Behavioral Sciences, University of California, San Francisco, San Francisco, CA 94110, USA.

Abstract

Therapeutic targeting of an extended-closed conformation of the integrin αvβ8 inhibits TGF-β activation and ameliorates symptoms of experimental airway disease in mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference62 articles.

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