Rapid Evolution of HIV-1 to Functional CD8 + T Cell Responses in Humanized BLT Mice-Reference-Cited by-同舟云学术

Rapid Evolution of HIV-1 to Functional CD8 + T Cell Responses in Humanized BLT Mice

Published:2012-07-18 Issue:143 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Dudek Timothy E.¹,No Daniel C.¹,Seung Edward²,Vrbanac Vladimir D.²,Fadda Lena¹,Bhoumik Priyasma¹,Boutwell Christian L.¹,Power Karen A.¹,Gladden Adrianne D.¹,Battis Laura¹,Mellors Elizabeth F.¹,Tivey Trevor R.²,Gao Xiaojiang³,Altfeld Marcus¹,Luster Andrew D.²,Tager Andrew M.²,Allen Todd M.¹

Affiliation:

1. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Charlestown, MA 02129, USA.

2. Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

3. Cancer and Immunology Program, Laboratory of Experimental Immunology, Science Applications International Corporation-Frederick, National Cancer Institute-Frederick, Frederick, MD 20882, USA.

Abstract

Humanized BLT mice accurately develop human HIV-specific CD8 + T cell responses capable of rapidly selecting for CTL escape mutations.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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