Ser 1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations-Reference-Cited by-同舟云学术

Ser 1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

Published:2012-12-12 Issue:164 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sheng Zejuan¹,Zhang Shuo¹,Bustos Daisy²,Kleinheinz Tracy³,Le Pichon Claire E.¹,Dominguez Sara L.¹,Solanoy Hilda O.¹,Drummond Jason³,Zhang Xiaolin⁴,Ding Xiao⁴,Cai Fang⁵,Song Qinghua⁶,Li Xianting⁷,Yue Zhenyu⁷,van der Brug Marcel P.⁵,Burdick Daniel J.⁸,Gunzner-Toste Janet⁸,Chen Huifen⁸,Liu Xingrong⁴,Estrada Anthony A.⁸,Sweeney Zachary K.⁸,Scearce-Levie Kimberly¹,Moffat John G.³,Kirkpatrick Donald S.²,Zhu Haitao¹

Affiliation:

1. Department of Neurosciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

2. Department of Protein Chemistry, Genentech, South San Francisco, CA 94080, USA.

3. Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA 94080, USA.

4. Department of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, USA.

5. Department of Diagnostics Discovery, Genentech, South San Francisco, CA 94080, USA.

6. Department of Non-clinical Statistics, Genentech, South San Francisco, CA 94080, USA.

7. Department of Neurology and Neuroscience, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

8. Department of Discovery Chemistry, Genentech, South San Francisco, CA 94080, USA.

Abstract

LRRK2 autophosphorylation on Ser 1292 may be a useful indicator of kinase activity, providing a readout for screening candidate LRRK2 inhibitors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference50 articles.

1. Priorities in Parkinson's disease research

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