Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV-Reference-Cited by-同舟云学术

Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV

Published:2014-05-14 Issue:236 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sok Devin¹²³,Doores Katie J.¹²³⁴,Briney Bryan¹²³,Le Khoa M.¹²³,Saye-Francisco Karen L.¹²³,Ramos Alejandra¹²³⁵,Kulp Daniel W.¹²³⁵,Julien Jean-Philippe²³⁶,Menis Sergey¹²³⁵,Wickramasinghe Lalinda¹²³⁵,Seaman Michael S.⁷,Schief William R.¹²³⁵⁸,Wilson Ian A.²³⁶⁹,Poignard Pascal¹²⁵,Burton Dennis R.¹²³⁸

Affiliation:

1. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

3. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA.

4. Department of Infectious Diseases, King’s College London School of Medicine, Guy’s Hospital, London SE1 9RT, UK.

5. International AIDS Vaccine Initiative, New York, NY 10038, USA.

6. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

7. Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

8. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Boston, MA 02142, USA.

9. Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

HIV broadly neutralizing monoclonal antibodies targeting the high-mannose patch of Env can use alternate glycan sites for neutralization.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference44 articles.

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