Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population-Reference-Cited by-同舟云学术

Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population

Published:2009-11-04 Issue:5 Volume:1 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Matsuo Hirotaka¹,Takada Tappei²,Ichida Kimiyoshi³⁴,Nakamura Takahiro⁵⁶,Nakayama Akiyoshi¹⁷,Ikebuchi Yuki²,Ito Kousei²,Kusanagi Yasuyoshi¹,Chiba Toshinori¹,Tadokoro Shin¹,Takada Yuzo⁸,Oikawa Yuji⁹,Inoue Hiroki¹,Suzuki Koji¹⁰,Okada Rieko¹¹,Nishiyama Junichiro¹²,Domoto Hideharu¹³,Watanabe Satoru¹⁴,Fujita Masanori¹⁴,Morimoto Yuji¹,Naito Mariko¹¹,Nishio Kazuko¹¹,Hishida Asahi¹¹,Wakai Kenji¹¹,Asai Yatami¹⁵,Niwa Kazuki⁹,Kamakura Keiko¹⁶,Nonoyama Shigeaki¹⁷,Sakurai Yutaka¹⁸,Hosoya Tatsuo⁴,Kanai Yoshikatsu¹⁹,Suzuki Hiroshi²,Hamajima Nobuyuki¹¹,Shinomiya Nariyoshi¹

Affiliation:

1. Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.

2. Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan.

3. Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan.

4. Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105-8461, Japan.

5. Laboratory for Mathematics, Premedical Course, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.

6. Laboratory for Statistical Analysis, Center for Genomic Medicine, Institute of Physical and Chemical Research, Tokyo 108-8639, Japan.

7. Medical Platoon, 9th Aircraft Control and Warning Squadron, Japan Air Self-Defense Force, Satsuma-Sendai, Kagoshima 896-1411, Japan.

8. Department of Forensic Medicine, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.

9. Department of Biology, Faculty of Science, Toho University, Funabashi, Chiba 274-8510, Japan.

10. Department of Public Health, Fujita Health University, School of Health Sciences, Toyoake, Aichi 470-1192, Japan.

11. Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.

12. Japan Self-Defense Forces Hospital Yokosuka, Yokosuka, Kanagawa 237-0071, Japan.

13. Medical Service Unit Kure, Japan Maritime Self-Defense Force, Kure, Hiroshima 737-8554, Japan.

14. Division of Environmental Medicine, National Defense Medical College Research Institute, Tokorozawa, Saitama 359-8513, Japan.

15. Seirei Social Welfare Community, Hamamatsu, Shizuoka 430-0946, Japan.

16. Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.

17. Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.

18. Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.

19. Division of Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.

Abstract

Dysfunctional genotype combinations of polymorphic adenosine 5′-triphosphate–binding cassette transporter gene ABCG2/BCRP , which encodes a high-capacity urate secretion transporter in human gut and kidney, are major causes of gout.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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