DNA Methylation Alterations Exhibit Intraindividual Stability and Interindividual Heterogeneity in Prostate Cancer Metastases-Reference-Cited by-同舟云学术

DNA Methylation Alterations Exhibit Intraindividual Stability and Interindividual Heterogeneity in Prostate Cancer Metastases

Published:2013-01-23 Issue:169 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Aryee Martin J.¹²,Liu Wennuan³,Engelmann Julia C.¹,Nuhn Philipp¹,Gurel Meltem¹,Haffner Michael C.¹,Esopi David¹,Irizarry Rafael A.⁴,Getzenberg Robert H.¹⁵,Nelson William G.¹⁵,Luo Jun¹⁵,Xu Jianfeng³,Isaacs William B.¹⁵,Bova G. Steven⁶,Yegnasubramanian Srinivasan¹⁷

Affiliation:

1. Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA.

2. Oncology Department, Division of Biostatistics, Johns Hopkins University, Baltimore, MD 21231, USA.

3. Center for Cancer Genomics, Center for Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

4. Biostatistics Department, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

5. Brady Urological Institute, Johns Hopkins University, Baltimore, MD 21287, USA.

6. Pathology Department, Johns Hopkins University, Baltimore, MD 21287, USA.

7. Johns Hopkins Physical Sciences in Oncology Center, Johns Hopkins University, Baltimore, MD 21231, USA.

Abstract

Prostate tumors develop a unique epigenetic DNA methylation signature that is clonally maintained in disseminated metastases.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference58 articles.

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5. Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index

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