Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants-Reference-Cited by-同舟云学术

Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants

Published:2014-10-29 Issue:260 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Shenoi Rajesh A.¹,Kalathottukaren Manu Thomas¹,Travers Richard J.²,Lai Benjamin F. L.¹,Creagh A. Louise³,Lange Dirk⁴,Yu Kai¹,Weinhart Marie¹,Chew Ben H.⁴,Du Caigan⁴,Brooks Donald E.¹⁵,Carter Cedric J.¹,Morrissey James H.²,Haynes Charles A.³,Kizhakkedathu Jayachandran N.¹⁵

Affiliation:

1. Centre for Blood Research and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

2. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

3. Michael Smith Laboratories, Department of Chemical and Biological Engineering, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

4. Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.

5. Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

Abstract

A safe, synthetic anticoagulant-reversal agent based on a dendritic polymer is effective against all the clinical heparin anticoagulants and may be a treatment for bleeding in high-risk surgical procedures.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference59 articles.

1. Triggers, targets and treatments for thrombosis

2. Prophylaxis for Thromboembolism in Hospitalized Medical Patients

3. Heparin Overview and Issues

4. Low-Molecular-Weight Heparins

5. Emerging options in the treatment of deep vein thrombosis and pulmonary embolism

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