Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to β-Lactam Antibiotics-Reference-Cited by-同舟云学术

Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to β-Lactam Antibiotics

Published:2012-03-21 Issue:126 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Tan Christopher M.¹,Therien Alex G.¹,Lu Jun²,Lee Sang H.¹,Caron Alexandre³,Gill Charles J.¹,Lebeau-Jacob Christian³,Benton-Perdomo Liliana³,Monteiro João M.⁴,Pereira Pedro M.⁴,Elsen Nathaniel L.⁵,Wu Jin¹,Deschamps Kathleen¹,Petcu Mihai³,Wong Simon³,Daigneault Etienne³,Kramer Susanne¹,Liang Lianzhu¹,Maxwell Eugene¹,Claveau David³,Vaillancourt John³,Skorey Kathryn³,Tam John³,Wang Hao¹,Meredith Timothy C.³,Sillaots Susan³,Wang-Jarantow Lisa¹,Ramtohul Yeeman³,Langlois Eric³,Landry France³,Reid John C.²,Parthasarathy Gopal²,Sharma Sujata⁵,Baryshnikova Anastasia⁶,Lumb Kevin J.⁵,Pinho Mariana G.⁴,Soisson Stephen M.²,Roemer Terry¹

Affiliation:

1. Infectious Diseases, Merck Research Laboratories, Kenilworth, NJ 07033, USA.

2. Global Structural Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.

3. Merck Frosst Canada, Kirkland, Quebec H9H 3L1, Canada.

4. Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2781-901 Oeiras, Portugal.

5. Screening and Protein Science, Merck Research Laboratories, West Point, PA 19486, USA.

6. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

Abstract

Methicillin-resistant Staphylococcus aureus infection can be treated effectively by combining a β-lactam antibiotic with a drug that targets FtsZ.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference57 articles.

1. C. Walsh Antibiotics: Actions Origins Resistance (ASM Press Washington DC 2003).

2. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

3. The future of the β-lactams

4. Newer antibacterial drugs for a new century

5. Antibiotic resistant Staphylococcus aureus: a paradigm of adaptive power

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