A Molecular Signature Predictive of Indolent Prostate Cancer

Author:

Irshad Shazia1,Bansal Mukesh2,Castillo-Martin Mireia3,Zheng Tian45,Aytes Alvaro1,Wenske Sven14,Le Magnen Clémentine1,Guarnieri Paolo24,Sumazin Pavel2,Benson Mitchell C.14,Shen Michael M.2467,Califano Andrea248910,Abate-Shen Cory12411

Affiliation:

1. Department of Urology, Columbia University Medical Center, New York, NY 10029, USA.

2. Department of Systems Biology, Columbia University Medical Center, New York, NY 10029, USA.

3. Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

4. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.

5. Department of Statistics, Columbia University, New York, NY 10027, USA.

6. Department of Medicine, Columbia University Medical Center, New York, NY 10029, USA.

7. Department of Genetics and Development, Columbia University Medical Center, New York, NY 10029, USA.

8. Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10029, USA.

9. Department of Biomedical Informatics, Columbia University Medical Center, New York, NY 10029, USA.

10. Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10029, USA.

11. Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10029, USA.

Abstract

A three-gene panel derived from mechanistic models of cell senescence predicts outcome of low Gleason score prostate tumors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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