BPIFB1 Is a Lung-Specific Autoantigen Associated with Interstitial Lung Disease

Author:

Shum Anthony K.1,Alimohammadi Mohammad2,Tan Catherine L.3,Cheng Mickie H.3,Metzger Todd C.3,Law Christopher S.1,Lwin Wint1,Perheentupa Jaakko4,Bour-Jordan Helene3,Carel Jean Claude567,Husebye Eystein S.89,De Luca Filippo10,Janson Christer2,Sargur Ravishankar11,Dubois Noémie12,Kajosaari Merja13,Wolters Paul J.1,Chapman Harold A.1,Kämpe Olle2,Anderson Mark S.3

Affiliation:

1. Division of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

2. University Hospital, Uppsala University, S-751 85 Uppsala, Sweden.

3. Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.

4. Hospital for Children and Adolescents, University of Helsinki, Box 281, Fin-00029 HUS Helsinki, Finland.

5. Univ Paris Diderot, Sorbonne Paris Cité, F-75019 Paris, France.

6. Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Department of Pediatric Endocrinology and Diabetology, and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, F-75019 Paris, France.

7. INSERM Unité CIE-5, F-75019 Paris, France.

8. Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.

9. Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway.

10. Department of Pediatrics, University of Messina, 98126 Messina Gazzi, Italy.

11. Department of Immunology, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, UK.

12. Department of Nutrition, Metabolic Diseases and Endocrinology, La Timone Hospital, Centre Hospitalier Universitaire de Marseille, 13385 Marseille cedex 05, France.

13. Hospital for Children and Adolescents, University of Helsinki, Fin-00029 HUS Helsinki, Finland.

Abstract

Autoimmunity targeting the lung-specific antigen BPIFB1 may be important to the pathogenesis of interstitial lung disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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