Modeling an Anti-Amyloid Combination Therapy for Alzheimer’s Disease-Reference-Cited by-同舟云学术

Modeling an Anti-Amyloid Combination Therapy for Alzheimer’s Disease

Published:2010-01-06 Issue:13 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chow Vivian W.¹,Savonenko Alena V.¹²,Melnikova Tatiana¹,Kim Hyunsu¹,Price Donald L.¹²³,Li Tong¹,Wong Philip C.¹³

Affiliation:

1. Department of Pathology, Johns Hopkins University School of Medicine, 558 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205, USA.

2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

3. Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Simultaneous reduction of two of the enzymes that create the plaque-forming peptide β-amyloid in Alzheimer’s disease ameliorates symptoms in aged mice better than elimination of either enzyme alone.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference53 articles.

1. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2. Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective

3. Genetically engineered mouse models of neurodegenerative diseases

4. Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

5. Epidermal Growth Factor Receptor and Notch Pathways Participate in the Tumor Suppressor Function of γ-Secretase

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