Making Prospective Registration of Observational Research a Reality

Author:

Dal-Ré Rafael123,Ioannidis John P.43,Bracken Michael B.53,Buffler Patricia A.6,Chan An-Wen7,Franco Eduardo L.8,La Vecchia Carlo9,Weiderpass Elisabete10

Affiliation:

1. Clinical Research Program, Pasqual Maragall Foundation, E-08003 Barcelona, Spain.

2. Current address: BUC (Biosciences UAM+CSIC) Program, International Campus of Excellence, Universidad Autónoma, E-28049 Madrid, Spain

3. These authors contributed equally to this work.

4. Stanford Prevention Research Center, Department of Medicine, and Department of Health Research and Policy, Stanford University School of Medicine, Department of Statistics, Stanford University School of Humanities and Sciences, and Meta-research Innovation Center at Stanford (METRICS), Stanford, CA 94305, USA.

5. Center for Perinatal, Pediatric and Environmental Epidemiology Schools of Public Health and Medicine, Yale University, New Haven, CT 06510–3330, USA.

6. Division of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720–6667, USA.

7. Women’s College Research Institute, Women’s College Hospital, Department of Medicine, and Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario M5G 1N8, Canada.

8. Departments of Oncology and Epidemiology and Biostatistics, McGill University, Montreal, Quebec, H2W 1S6, Canada.

9. Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri and Department of Clinical Sciences and Community Health, University of Milan, Milan I-20156, Italy.

10. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden; Department of Research, Cancer Registry of Norway, Oslo NO-0304, Norway; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø NO-9037, Norway; and Samfundet Folkhälsan, Helsinki FI-00014, Finland.

Abstract

Key information about human observational studies should be publicly available before the study is initiated.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference39 articles.

1. European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) Workshop: Enhancement of the scientific process and transparency of observational epidemiology studies. (Brussels Belgium November 2009).http://members.ecetoc.org/Documents/Document/20100108131222-WR_18.pdf.

2. Should protocols for observational research be registered?

3. The Registration of Observational Studies—When Metaphors Go Bad

4. Preregistration of Study Protocols Is Unlikely to Improve the Yield From Our Science, But Other Strategies Might

5. Preregistration of Epidemiologic Studies

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