Vascular Catheters with a Nonleaching Poly-Sulfobetaine Surface Modification Reduce Thrombus Formation and Microbial Attachment

Author:

Smith Roger S.1,Zhang Zheng1,Bouchard Michael1,Li Jun1,Lapp Heather S.1,Brotske Gregory R.1,Lucchino David L.1,Weaver Douglas1,Roth Laurence A.1,Coury Arthur2,Biggerstaff John3,Sukavaneshvar Sivaprasad4,Langer Robert5,Loose Christopher1

Affiliation:

1. Semprus BioSciences Corp., Cambridge, MA 02139, USA.

2. Coury Consulting Services, Boston, MA 02116, USA.

3. Center for Environmental Biotechnology, University of Tennessee, Knoxville, TN 37996, USA.

4. Thrombodyne, Salt Lake City, UT 84103, USA.

5. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Poly-sulfobetaine surface modification on a vascular catheter inhibits microbial adherence and thrombosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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