Transferred WT1-Reactive CD8 + T Cells Can Mediate Antileukemic Activity and Persist in Post-Transplant Patients-Reference-Cited by-同舟云学术

Transferred WT1-Reactive CD8 + T Cells Can Mediate Antileukemic Activity and Persist in Post-Transplant Patients

Published:2013-02-27 Issue:174 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chapuis Aude G.¹,Ragnarsson Gunnar B.¹,Nguyen Hieu N.¹,Chaney Colette N.¹,Pufnock Jeffrey S.¹,Schmitt Thomas M.¹,Duerkopp Natalie¹,Roberts Ilana M.¹,Pogosov Galina L.²,Ho William Y.¹,Ochsenreither Sebastian¹,Wölfl Matthias¹,Bar Merav²,Radich Jerald P.²,Yee Cassian¹,Greenberg Philip D.¹³

Affiliation:

1. Program in Immunology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA 98109, USA.

2. Clinical Research Division, FHCRC, Seattle, WA 98109, USA.

3. Department of Immunology, University of Washington, Seattle, WA 98195, USA.

Abstract

Donor-derived WT1-specific CD8 + T cells transferred after hematopoietic cell transplantation mediate antileukemic activity and can establish persistent responses without toxicity to normal tissues in high-risk leukemia patients.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference56 articles.

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2. Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts

3. CTLs Specific for bcr-abl Joining Region Segment Peptides Fail to Lyse Leukemia Cells Expressing p210 bcr-abl Protein

4. The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed

5. The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research

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