A Central Role for Free Heme in the Pathogenesis of Severe Sepsis-Reference-Cited by-同舟云学术

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

Published:2010-09-29 Issue:51 Volume:2 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Larsen Rasmus¹,Gozzelino Raffaella¹,Jeney Viktória¹,Tokaji László¹,Bozza Fernando A.²³,Japiassú André M.²³,Bonaparte Dolores¹,Cavalcante Moisés Marinho¹,Chora Ângelo¹,Ferreira Ana¹,Marguti Ivo¹,Cardoso Sílvia¹,Sepúlveda Nuno¹⁴,Smith Ann⁵,Soares Miguel P.¹

Affiliation:

1. Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal.

2. Intensive Care Unit, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, 21040-900 Rio de Janeiro, Brazil.

3. D’Or Institute for Research and Education, 22281-100 Rio de Janeiro, Brazil.

4. Center of Statistics and Applications of the University of Lisbon, Campo Grande, 1749-016 Lisbon, Portugal.

5. Division of Molecular Biology and Biochemistry, University of Missouri, 5007 Rockhill Road, Kansas City, MO 64110, USA.

Abstract

Heme from red blood cells released in septic shock worsens organ dysfunction and increases the risk of death, but can be overcome by a scavenger of free heme.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference51 articles.

1. The Epidemiology of Sepsis in the United States from 1979 through 2000

2. The immunopathogenesis of sepsis

3. Origin and physiological roles of inflammation

4. Animal Defenses against Infectious Agents: Is Damage Control More Important Than Pathogen Control

5. Tolerance to Plant Disease

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