CD4 T Cells with Effector Memory Phenotype and Function Develop in the Sterile Environment of the Fetus-Reference-Cited by-同舟云学术

CD4 T Cells with Effector Memory Phenotype and Function Develop in the Sterile Environment of the Fetus

Published:2014-05-28 Issue:238 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhang Xiaoming¹²³,Mozeleski Brian¹²,Lemoine Sebastien¹²,Dériaud Edith¹²,Lim Annick⁴,Zhivaki Dania¹²,Azria Elie⁵⁶,Le Ray Camille⁷⁸,Roguet Gwenaelle⁹,Launay Odile⁸⁹¹⁰,Vanet Anne¹¹¹²¹³,Leclerc Claude¹²,Lo-Man Richard¹²

Affiliation:

1. Régulation Immunitaire et Vaccinologie, Institut Pasteur, F-75724 Paris, France.

2. INSERM U1041, F-75724 Paris, France.

3. Unit of Innate Defense and Immune Modulation, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200025, China.

4. Department Immunology, Institut Pasteur, F-75724 Paris, France.

5. Department of Obstetrics and Gynecology, Hospital Bichat Claude Bernard, 75018 Paris, France.

6. Paris 7 Diderot University, F-75013 Paris, France.

7. Assistance Publique–Hôpitaux de Paris (AP-HP), Department of Obstetrics and Gynecology, Maternité Port Royal, F-75014 Paris, France.

8. Université Paris Descartes, Sorbonne Paris Cité, F-75005 Paris, France.

9. INSERM CIC1417, F-75014 Paris, France.

10. AP-HP, Hopital Cochin, F-75014 Paris, France.

11. Univ Paris Diderot, Sorbonne Paris Cité, F-75013 Paris, France.

12. CNRS, UMR7592, Institut Jacques Monod, F-75013 Paris, France.

13. Atelier de Bio Informatique, F-75005 Paris, France.

Abstract

Umbilical cord blood from healthy neonates with no known infectious exposure contains T cells with an effector memory–like phenotype.